GR 55562 dihydrochloride

Name: GR 55562 dihydrochloride
Brand: MedChemExpress
SKU: HY-101367A
Rating: 4.5 (1 reviews)

Cat. No.: HY-101367A Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

GR 55562 dihydrochloride is a selective 5-HT_1B receptor antagonist. GR 55562 dihydrochloride can be used for the research of nerve disease.

For research use only. We do not sell to patients.

GR 55562 dihydrochloride Chemical Structure

CAS No. : 159533-25-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GR 55562 dihydrochloride:

GR 55562 hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

GR 55562 dihydrochloride is a selective 5-HT_1B receptor antagonist. GR 55562 dihydrochloride can be used for the research of nerve disease^[1].

In Vivo

GR 55562 (0.1-10 μg/side) into accumbens subregions did not evoke cocaine-lever responding^[1].
GR 55562 (0.1-10 μg/side) in the accumbens shell or core failed to modulate the discriminative stimulus effects of cocaine (5 mg/kg)^[1].
GR 55562 (1 μg/side) significantly attenuated the enhancement of cocaine discrimination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (280-300 g; n=50)^[1].
Dosage:	0.1-10 μg/side
Administration:	Injected intracranially; At a volume of 0.2 µl/side
Result:	Did not evoke substitution for the drug with intra-accumbal shell infusion. Did not significantly affect the discriminative stimulus effects produced by 5 mg/kg of cocaine. GR 55562 (1 µg/side) attenuated the enhancement of cocaine discrimination evoked by a combination of intra-accumbal core CP 93129 (1 µg/side) and systemic cocaine (1.25 mg/ kg or 2.5 mg/kg).

Molecular Weight

448.39

Formula

C₂₃H₂₇Cl₂N₃O₂

CAS No.

159533-25-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=C(C2=CC=NC=C2)C=C1)C3=CC=C(O)C(CCCN(C)C)=C3.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 44.8 mg/mL (99.91 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2302 mL	11.1510 mL	22.3020 mL
5 mM	0.4460 mL	2.2302 mL	4.4604 mL
10 mM	0.2230 mL	1.1151 mL	2.2302 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (247 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)

References

[1]. Filip M, et al. Effects of serotonin (5-HT)(1B) receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(3):226-234. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.2302 mL	11.1510 mL	22.3020 mL	55.7550 mL
	5 mM	0.4460 mL	2.2302 mL	4.4604 mL	11.1510 mL
	10 mM	0.2230 mL	1.1151 mL	2.2302 mL	5.5755 mL
	15 mM	0.1487 mL	0.7434 mL	1.4868 mL	3.7170 mL
	20 mM	0.1115 mL	0.5576 mL	1.1151 mL	2.7878 mL
	25 mM	0.0892 mL	0.4460 mL	0.8921 mL	2.2302 mL
	30 mM	0.0743 mL	0.3717 mL	0.7434 mL	1.8585 mL
	40 mM	0.0558 mL	0.2788 mL	0.5576 mL	1.3939 mL
	50 mM	0.0446 mL	0.2230 mL	0.4460 mL	1.1151 mL
	60 mM	0.0372 mL	0.1859 mL	0.3717 mL	0.9293 mL
	80 mM	0.0279 mL	0.1394 mL	0.2788 mL	0.6969 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.