2. GPCR/G Protein
  3. G Protein-coupled Receptor Kinase (GRK)
  4. GRL018-21

GRL018-21 is a potent and highly selective G protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 value of 10 nM.

For research use only. We do not sell to patients.

GRL018-21 Chemical Structure

GRL018-21 Chemical Structure

Size Price Stock Quantity
5 mg USD 345 In-stock
10 mg USD 550 In-stock
25 mg USD 1100 In-stock
50 mg USD 1750 In-stock
100 mg USD 2600 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

GRL018-21 Related Antibodies

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Description

GRL018-21 is a potent and highly selective G protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 value of 10 nM[1].

Molecular Weight

540.54

Formula

C30H25FN4O5
Appearance

Solid

Color

Orange to red

SMILES

FC1=CC=C([C@@H](C)NC(C2=CC=C(NC(/C3=C\C4=C(C)C(NC(C(C5=CC=CO5)=O)=O)=C(C)N4)=O)C3=C2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (64.75 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8500 mL 9.2500 mL 18.5000 mL
5 mM 0.3700 mL 1.8500 mL 3.7000 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8500 mL 9.2500 mL 18.5000 mL 46.2500 mL
5 mM 0.3700 mL 1.8500 mL 3.7000 mL 9.2500 mL
10 mM 0.1850 mL 0.9250 mL 1.8500 mL 4.6250 mL
15 mM 0.1233 mL 0.6167 mL 1.2333 mL 3.0833 mL
20 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3125 mL
25 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8500 mL
30 mM 0.0617 mL 0.3083 mL 0.6167 mL 1.5417 mL
40 mM 0.0463 mL 0.2313 mL 0.4625 mL 1.1563 mL
50 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9250 mL
60 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
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GRL018-21 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRL018-21G Protein-coupled Receptor Kinase (GRK)GRK5 inhibitorInhibitorinhibitorinhibit

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