2. Anti-infection
  3. HCV
  4. GS-6620

GS-6620 is potent and selective pangenotype HCV inhibitor against HCV replicons of genotypes 1 to 6 (EC50: 0.048 to 0.68 μM). GS-6620 shows limited activities against other viruses, maintaining only some of its activity against the closely related bovine viral diarrhea virus (EC50, 1.5 μM).

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GS-6620 Chemical Structure

GS-6620 Chemical Structure

CAS No. : 1350735-70-4

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Based on 1 publication(s) in Google Scholar

GS-6620 Related Antibodies

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Description

GS-6620 is potent and selective pangenotype HCV inhibitor against HCV replicons of genotypes 1 to 6 (EC50: 0.048 to 0.68 μM). GS-6620 shows limited activities against other viruses, maintaining only some of its activity against the closely related bovine viral diarrhea virus (EC50, 1.5 μM)[1].

IC50 & Target

IC50: 48-680 nM (HCV replicons of genotypes 1 to 6)[1]
Cellular Effect
Cell Line Type Value Description References
Huh-7 EC50
0.61 μM
Compound: 16
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay
[PMID: 23547794]
Huh-7 CC50
47 μM
Compound: 16
Cytotoxicity against human HuH7 cells after 3 days by fluorescence assay
Cytotoxicity against human HuH7 cells after 3 days by fluorescence assay
[PMID: 23547794]
Molecular Weight

644.61

Formula

C29H37N6O9P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#C[C@](O[C@@H]1CO[P@](OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)(C3=CC=C4N3N=CN=C4N)[C@](O)([C@@H]1OC(C(C)C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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GS-6620 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-66201350735-70-4GS6620GS 6620HCVHepatitis C virusInhibitorinhibitorinhibit

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HY-12633
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