2. GPCR/G Protein
  3. Adenosine Receptor
  4. GS-9667

GS-9667 (CVT 3619), a novel N6-5'-substituted adenosine analog, is a selective, partial agonist of the A1 adenosine receptor (A1AdoR). GS-9667 binds to adipocyte membranes with high (KH=14 nM) and low (KL=5.4 μM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).

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GS-9667 Chemical Structure

GS-9667 Chemical Structure

CAS No. : 618380-90-8

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1 mg USD 140 In-stock
5 mg USD 350 In-stock
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50 mg USD 1100 In-stock
100 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

GS-9667 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

GS-9667 (CVT 3619), a novel N6-5'-substituted adenosine analog, is a selective, partial agonist of the A1 adenosine receptor (A1AdoR). GS-9667 binds to adipocyte membranes with high (KH=14 nM) and low (KL=5.4 μM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA)[1][2].

Molecular Weight

461.51

Formula

C21H24FN5O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O[C@H]1[C@@H](O[C@@H]([C@H]1O)CSC2=C(C=CC=C2)F)N3C4=NC=NC(N[C@H]5[C@@H](CCC5)O)=C4N=C3
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (270.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1668 mL 10.8340 mL 21.6680 mL
5 mM 0.4334 mL 2.1668 mL 4.3336 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1668 mL 10.8340 mL 21.6680 mL 54.1700 mL
5 mM 0.4334 mL 2.1668 mL 4.3336 mL 10.8340 mL
10 mM 0.2167 mL 1.0834 mL 2.1668 mL 5.4170 mL
15 mM 0.1445 mL 0.7223 mL 1.4445 mL 3.6113 mL
20 mM 0.1083 mL 0.5417 mL 1.0834 mL 2.7085 mL
25 mM 0.0867 mL 0.4334 mL 0.8667 mL 2.1668 mL
30 mM 0.0722 mL 0.3611 mL 0.7223 mL 1.8057 mL
40 mM 0.0542 mL 0.2709 mL 0.5417 mL 1.3543 mL
50 mM 0.0433 mL 0.2167 mL 0.4334 mL 1.0834 mL
60 mM 0.0361 mL 0.1806 mL 0.3611 mL 0.9028 mL
80 mM 0.0271 mL 0.1354 mL 0.2709 mL 0.6771 mL
100 mM 0.0217 mL 0.1083 mL 0.2167 mL 0.5417 mL
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GS-9667 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-9667618380-90-8CVT 3619GS9667GS 9667CVT3619CVT-3619Adenosine ReceptorP1 receptorN6-5'-substituted adenosineA1 adenosine receptorA1AdoRadipocyte membranecyclic AMPfatty acidlipolysisfree fatty acidsFFAInhibitorinhibitorinhibit

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