Guanosine 5'-triphosphate-5'-adenosine (Synonyms: GpppA)

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Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog.

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Guanosine 5′-(tetrahydrogen triphosphate), P′′→5′-ester with adenosine

Guanosine 5'-triphosphate-5'-adenosine Chemical Structure

CAS No. : 10527-47-6

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Other Forms of Guanosine 5'-triphosphate-5'-adenosine:

Guanosine 5'-triphosphate-5'-adenosine triammonium Get quote

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Description

Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Guanosine 5'-triphosphate-5'-adenosine (GpppA) labeled with pyrene at the 3′‐O position of adenosine acts as an artificial substrate. Fluorescently labeled Guanosine 5'-triphosphate-5'-adenosine (GpppA) and GpppG analogs as potential substrates that represent a reasonable compromise between the structural complexity and requirements of the enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

772.41

Formula

C₂₀H₂₇N₁₀O₁₇P₃

CAS No.

10527-47-6

SMILES

O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C23)O1)OP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C(NC(N)=N6)=C(N=C5)C6=O)O4)(O)=O)(O)=O

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Renata Kasprzyk, et al. Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity. Chemistry. 2020 Sep 1;26(49):11266-11275. [Content Brief]

[2]. Dennis Reichert, et al. Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1. Chem Sci. 2021 Feb 8;12(12):4383-4388. [Content Brief]

Guanosine 5'-triphosphate-5'-adenosine Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanosine 5'-triphosphate-5'-adenosine10527-47-6GpppADNA/RNA SynthesisEndogenous MetaboliteInhibitorinhibitorinhibit

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