2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase Angiotensin-converting Enzyme (ACE)
  4. H-Tyr-Phe-OH

H-Tyr-Phe-OH  (Synonyms: L-Tyrosyl-L-phenylalanine)

Cat. No.: HY-W011258 Purity: 99.46%
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H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells.

For research use only. We do not sell to patients.

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H-Tyr-Phe-OH Chemical Structure

H-Tyr-Phe-OH Chemical Structure

CAS No. : 17355-11-2

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Description

H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4].

IC50 & Target

Target: ACE (Angiotensin converting enzyme), xanthine oxidase[1]
Molecular Weight

328.36

Formula

C18H20N2O4
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (15.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0454 mL 15.2272 mL 30.4544 mL
5 mM 0.6091 mL 3.0454 mL 6.0909 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0454 mL 15.2272 mL 30.4544 mL 76.1360 mL
5 mM 0.6091 mL 3.0454 mL 6.0909 mL 15.2272 mL
10 mM 0.3045 mL 1.5227 mL 3.0454 mL 7.6136 mL
15 mM 0.2030 mL 1.0151 mL 2.0303 mL 5.0757 mL
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H-Tyr-Phe-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Tyr-Phe-OH17355-11-2L-Tyrosyl-L-phenylalanineXanthine OxidaseAngiotensin-converting Enzyme (ACE)XOThyroid cancerTCBenign Thyroid noduleBTNKeratintype II cytoskeletal lbVariable immnoglobul in anti-estradiol heavy chainuric acid loweringxanthine oxidaseIL-8neutrophil-like cellsInhibitorinhibitorinhibit

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