2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. hAChE/Aβ1-42-IN-1

hAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. hAChE/Aβ1-42-IN-1 shows acceptable relative safety upon hepG2 cell line and excellent BBB penetration with wide safety margin. hAChE/Aβ1-42-IN-1 has the potential for the research of Alzheimer disease (AD).

For research use only. We do not sell to patients.

hAChE/Aβ1-42-IN-1 Chemical Structure

hAChE/Aβ1-42-IN-1 Chemical Structure

CAS No. : 2761149-17-9

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hAChE/Aβ1-42-IN-1 Related Antibodies

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Description

hAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. hAChE/Aβ1-42-IN-1 shows acceptable relative safety upon hepG2 cell line and excellent BBB penetration with wide safety margin. hAChE/Aβ1-42-IN-1 has the potential for the research of Alzheimer disease (AD)[1].

IC50 & Target

AChE

 

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
25 μM
Compound: 16
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 35101650]
Molecular Weight

364.44

Formula

C20H24N6O
CAS No.
SMILES

O=C(NC1=NNC2=NC=CC=C21)CCN3CCN(CC3)CC4=CC=CC=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hAChE/Aβ1-42-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hAChE/Aβ1-42-IN-12761149-17-9Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetahAChEAβ1-42 aggregationsafetyBBB penetrationAlzheimer diseaseInhibitorinhibitorinhibit

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