2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. Haspin Kinase CDK DYRK
  4. Haspin-IN-2

Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC50 of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 445 nM and 917 nM, respectively.

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Haspin-IN-2 Chemical Structure

Haspin-IN-2 Chemical Structure

CAS No. : 2768474-47-9

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Haspin-IN-2 Related Antibodies

Top Publications Citing Use of Products

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DYRK1 DYRK2 DYRK3 DYRK4

  • Biological Activity

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Description

Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC50 of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 445 nM and 917 nM, respectively[1].

IC50 & Target[1]

Haspin Kinase

50 nM (IC50)

CLK1

445 nM (IC50)

DYRK1A

917 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HBL-100 EC50
8.5 μM
Compound: 4
Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
HCT-116 EC50
6.2 μM
Compound: 4
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
SH-SY5Y EC50
4.4 μM
Compound: 4
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
TERT-RPE1 EC50
3.2 μM
Compound: 4
Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
U2OS EC50
5.8 μM
Compound: 4
Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
Molecular Weight

256.22

Formula

C12H8N4O3
CAS No.
SMILES

COC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Haspin-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Haspin-IN-22768474-47-9Haspin KinaseCDKDYRKCyclin dependent kinaseDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseCLK1DYRK1AanticancerInhibitorinhibitorinhibit

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