HATU

Cat. No.: HY-Y1703 Purity: 99.98%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU can be used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds.

For research use only. We do not sell to patients.

HATU Chemical Structure

CAS No. : 148893-10-1

Size	Stock	Quantity
Free Sample (0.1 - 0.5 mg)	Apply Now
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

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This product is a controlled substance and not for sale in your territory.

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Description

Molecular Weight

380.23

Formula

C₁₀H₁₅F₆N₆OP

CAS No.

148893-10-1

Appearance

Solid

Color

White to off-white

SMILES

F[P-](F)(F)(F)(F)F.C/[N+](C)=C(N(C)C)/ON1C2=NC=CC=C2N=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (526.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6300 mL	13.1499 mL	26.2999 mL
5 mM	0.5260 mL	2.6300 mL	5.2600 mL
10 mM	0.2630 mL	1.3150 mL	2.6300 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (269 KB) SDS (478 KB)

COA (249 KB) HNMR (129 KB) RP-HPLC (288 KB)

Handling Instructions (2659 KB)

References

[1]. Louis A, et al. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive. J. Am. Chem. Soc. 1993, 115, 10, 4397–4398

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6300 mL	13.1499 mL	26.2999 mL	65.7497 mL
	5 mM	0.5260 mL	2.6300 mL	5.2600 mL	13.1499 mL
	10 mM	0.2630 mL	1.3150 mL	2.6300 mL	6.5750 mL
	15 mM	0.1753 mL	0.8767 mL	1.7533 mL	4.3833 mL
	20 mM	0.1315 mL	0.6575 mL	1.3150 mL	3.2875 mL
	25 mM	0.1052 mL	0.5260 mL	1.0520 mL	2.6300 mL
	30 mM	0.0877 mL	0.4383 mL	0.8767 mL	2.1917 mL
	40 mM	0.0657 mL	0.3287 mL	0.6575 mL	1.6437 mL
	50 mM	0.0526 mL	0.2630 mL	0.5260 mL	1.3150 mL
	60 mM	0.0438 mL	0.2192 mL	0.4383 mL	1.0958 mL
	80 mM	0.0329 mL	0.1644 mL	0.3287 mL	0.8219 mL
	100 mM	0.0263 mL	0.1315 mL	0.2630 mL	0.6575 mL

HATU Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HATU148893-10-1Biochemical Assay Reagentspeptide couplingactive esterHünig's baseamide bondInhibitorinhibitorinhibit

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HATU

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