2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β Tau Protein
  4. hBChE-IN-1

hBChE-IN-1 (compound 4), a quinolizidinyl derivative, is a potent hBChE inhibitor (IC50=7 nM) and highly selective over hAChE. hBChE-IN-1 shows inhibitory activity against tau and Aβ40 protein aggregation, with IC50 values of 20 and 4.3 μM, respectively. hBChE-IN-1 can be used for Alzheimer's disease research.

For research use only. We do not sell to patients.

hBChE-IN-1 Chemical Structure

hBChE-IN-1 Chemical Structure

CAS No. : 1776948-12-9

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hBChE-IN-1 Related Antibodies

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Description

hBChE-IN-1 (compound 4), a quinolizidinyl derivative, is a potent hBChE inhibitor (IC50=7 nM) and highly selective over hAChE. hBChE-IN-1 shows inhibitory activity against tau and Aβ40 protein aggregation, with IC50 values of 20 and 4.3 μM, respectively. hBChE-IN-1 can be used for Alzheimer's disease research[1].

IC50 & Target

hBCHE

0.0070 ± 0 μM (IC50)

equine serum BChE

0.088 μM (IC50)

EeAChE

0.18 μM (IC50)

hAChE

7.84 ± 0.8 μM (IC50)

Molecular Weight

466.70

Formula

C27H34N2OS2
CAS No.
SMILES

[H][C@]12CCCCN1CCC[C@H]2CSCCCNC3=CC=C(C4=C3C(C5=CC=CC=C5S4)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hBChE-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hBChE-IN-11776948-12-9Cholinesterase (ChE)Amyloid-βTau Proteinβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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