2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. HDAC HSP
  4. HDAC6/HSP90-IN-1

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice.

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HDAC6/HSP90-IN-1 Chemical Structure

HDAC6/HSP90-IN-1 Chemical Structure

CAS No. : 2411955-43-4

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HDAC6/HSP90-IN-1 Related Antibodies

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Description

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].

IC50 & Target

HDAC6

4.32 nM (IC50)

HSP90

46.8 nM (IC50)

HDAC3

1312 nM (IC50)

HDAC1

1878 nM (IC50)

HDAC8

3720 nM (IC50)

Molecular Weight

511.61

Formula

C28H37N3O6
CAS No.
SMILES

CC(C1=C(C=C(C(C(N2CC3=CC=C(C=C3C2)NC(CCCCCCCCC(NO)=O)=O)=O)=C1)O)O)C
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Purity & Documentation
References
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HDAC6/HSP90-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6/HSP90-IN-12411955-43-4HDACHSPHistone deacetylasesHeat shock proteinsNSCLC cellsH1975 cellsIsoindolineProgrammed death-ligand 1 (PD-L1)Histone deacetylaseHeat shock proteinLung cancerimmunosuppressiveInhibitorinhibitorinhibit

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