2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC8-IN-12

HDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC50: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer.

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HDAC8-IN-12 Chemical Structure

HDAC8-IN-12 Chemical Structure

CAS No. : 3028095-13-5

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HDAC8-IN-12 Related Antibodies

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Description

HDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC50: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer[1].

IC50 & Target

IC50: 0.12 nM (HDAC8)[1]
Molecular Weight

331.32

Formula

C16H17N3O5
CAS No.
SMILES

CN(/C1=C\C2=CC=C(C(OC)=C2)/C=C/C(NO)=O)C(CNC1=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC8-IN-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8-IN-123028095-13-5HDACHistone deacetylasesInhibitorinhibitorinhibit

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