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  4. HDGFRP2/PSIP1-IN-1

HDGFRP2/PSIP1-IN-1  (Synonyms: 4-(4-Bromo-1H-pyrazol-5-yl)pyridine)

Cat. No.: HY-W023758
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HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 (HDGFRP2) and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma (DIPG). HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 μM; meanwhile, it has a Kd value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily.

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HDGFRP2/PSIP1-IN-1 Chemical Structure

HDGFRP2/PSIP1-IN-1 Chemical Structure

CAS No. : 166196-54-9

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HDGFRP2/PSIP1-IN-1 Related Antibodies

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Description

HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 (HDGFRP2) and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma (DIPG). HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 μM; meanwhile, it has a Kd value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily[1].

IC50 & Target

HDGFRP2/PSIP1-IN-1 与 HDGFRP2 结合的 Kd 值为 7 μM; 与 PSIP1 PWWP 结构域结合的 Kd 值为 27 μM; 对 HDGFRP3 的 Kd 值为 14 μM。
Molecular Weight

224.06

Formula

C8H6BrN3
CAS No.
Appearance

Solid

SMILES

BrC1=CNN=C1C2=CC=NC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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HDGFRP2/PSIP1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDGFRP2/PSIP1-IN-1166196-54-94-(4-Bromo-1H-pyrazol-5-yl)pyridineOthersPontine gliomaHDGFRP2/PSIP1 InhibitorInhibitorinhibitorinhibit

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