HE-S2

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HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity.

For research use only. We do not sell to patients.

HE-S2 Chemical Structure

CAS No. : 2939851-67-7

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Description	HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity^[1].
IC₅₀ & Target	PD-1/PD-L1 and TLR7/8 ^[1]
In Vitro	HE-S2 (10 ng; 30 min) effectively targets and binds with PD-L1in MC38 cells^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. HE-S2 Related Antibodies
Molecular Weight	787.95
Formula	C₃₈H₄₅N₉O₆S₂
CAS No.	2939851-67-7
SMILES	C[C@H](COC(NC1=CC=C(C[N+](C)(C)CC2=CC=C(CC3=CC=C(N=C(N)N=C4NCCCC)C4=N3)C=C2)C=C1)=O)SSC5=NC=C([N+]([O-])=O)C=C5.[H]C([O-])=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. He L, et al. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy. J Med Chem. 2021;64(21):15716-15726. [Content Brief]

HE-S2 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HE-S22939851-67-7PD-1/PD-L1Toll-like Receptor (TLR)Drug-Linker Conjugates for ADCPD-1/Programmed death-ligand 1AntitumorT cellsTLR7/8MC3B16C57BL/6 miceInhibitorinhibitorinhibit

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