Head activator neuropeptide

Name: Head activator neuropeptide
Brand: MedChemExpress
SKU: HY-P3840
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3840 Purity: 99.50%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Head activator neuropeptide Chemical Structure

CAS No. : 79943-68-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis^[1].

IC₅₀ & Target

GPR37^[1]

In Vitro

Head activator neuropeptide (2 nM, 0-60 min) stimulates internalisation of GPR37 in COS-7 cell transfected with GPR37-FLAG^[1].
Head activator neuropeptide (EC₅₀: 3.3 nM) increases in Ca²⁺ mobilisation in CHO-K1 cells transfected with apoaequorin and GPR37^[1].
Head activator neuropeptide (EC₅₀: 5.6 nM) stimulates a current increase in frog oocytes expressing GPR37^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1125.32

Formula

C₅₄H₈₄N₁₂O₁₄

CAS No.

79943-68-3

Appearance

Solid

Color

White to off-white

Sequence Shortening

Glp-PPGGSKVILF

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (88.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8886 mL	4.4432 mL	8.8864 mL
5 mM	0.1777 mL	0.8886 mL	1.7773 mL
10 mM	0.0889 mL	0.4443 mL	0.8886 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.50%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (249 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Rezgaoui M, et al. The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. J Cell Sci. 2006 Feb 1;119(Pt 3):542-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8886 mL	4.4432 mL	8.8864 mL	22.2159 mL
	5 mM	0.1777 mL	0.8886 mL	1.7773 mL	4.4432 mL
	10 mM	0.0889 mL	0.4443 mL	0.8886 mL	2.2216 mL
	15 mM	0.0592 mL	0.2962 mL	0.5924 mL	1.4811 mL
	20 mM	0.0444 mL	0.2222 mL	0.4443 mL	1.1108 mL
	25 mM	0.0355 mL	0.1777 mL	0.3555 mL	0.8886 mL
	30 mM	0.0296 mL	0.1481 mL	0.2962 mL	0.7405 mL
	40 mM	0.0222 mL	0.1111 mL	0.2222 mL	0.5554 mL
	50 mM	0.0178 mL	0.0889 mL	0.1777 mL	0.4443 mL
	60 mM	0.0148 mL	0.0741 mL	0.1481 mL	0.3703 mL
	80 mM	0.0111 mL	0.0555 mL	0.1111 mL	0.2777 mL