HeE1-2Tyr

Name: HeE1-2Tyr
Brand: MedChemExpress
SKU: HY-100749
Rating: 4.5 (1 reviews)

Cat. No.: HY-100749 Purity: 96.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC₅₀ of 27.6 µM) activity in vitro.

For research use only. We do not sell to patients.

HeE1-2Tyr Chemical Structure

CAS No. : 2245195-67-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 250	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 250	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 195	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1120	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Flavivirus RNA dependent RNA polymerases (RdRp)^[1]
SARS-CoV-2 RdRps>^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	> 100 μM Compound: 1; PBTZ	Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay	[PMID: 32435384]
Huh-7	EC₅₀	0.4 μM Compound: 1; PBTZ	Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay	[PMID: 32435384]
Huh-7	EC₅₀	1.7 μM Compound: 1; PBTZ	Antiviral activity against Dengue virus 4 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay Antiviral activity against Dengue virus 4 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay	[PMID: 32435384]
Huh-7	EC₅₀	2.1 μM Compound: 1; PBTZ	Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay	[PMID: 32435384]
Huh-7	EC₅₀	2.8 μM Compound: 1; PBTZ	Antiviral activity against Dengue virus 1 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay Antiviral activity against Dengue virus 1 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay	[PMID: 32435384]
Huh-7	EC₅₀	2.8 μM Compound: 1; PBTZ	Antiviral activity against Dengue virus 3 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay Antiviral activity against Dengue virus 3 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay	[PMID: 32435384]

In Vitro

HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC₅₀ of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC₅₀ ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM^[1].
Additionally, upon infection of human HEK 293 cells (CC₅₀ of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC₅₀ values ranging from 3.9 to 12 µM^[1].
HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

582.67

Formula

C₃₃H₃₀N₂O₆S

CAS No.

2245195-67-7

Appearance

Solid

Color

White to yellow

SMILES

OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC(C(C=C2C3=CC=CC=C3)=C4SC5=CC=C(OC6CCCCC6)C=C5N4C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (171.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7162 mL	8.5812 mL	17.1624 mL
5 mM	0.3432 mL	1.7162 mL	3.4325 mL
10 mM	0.1716 mL	0.8581 mL	1.7162 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.68%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (260 KB) HNMR (307 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235. [Content Brief]

[2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7162 mL	8.5812 mL	17.1624 mL	42.9059 mL
	5 mM	0.3432 mL	1.7162 mL	3.4325 mL	8.5812 mL
	10 mM	0.1716 mL	0.8581 mL	1.7162 mL	4.2906 mL
	15 mM	0.1144 mL	0.5721 mL	1.1442 mL	2.8604 mL
	20 mM	0.0858 mL	0.4291 mL	0.8581 mL	2.1453 mL
	25 mM	0.0686 mL	0.3432 mL	0.6865 mL	1.7162 mL
	30 mM	0.0572 mL	0.2860 mL	0.5721 mL	1.4302 mL
	40 mM	0.0429 mL	0.2145 mL	0.4291 mL	1.0726 mL
	50 mM	0.0343 mL	0.1716 mL	0.3432 mL	0.8581 mL
	60 mM	0.0286 mL	0.1430 mL	0.2860 mL	0.7151 mL
	80 mM	0.0215 mL	0.1073 mL	0.2145 mL	0.5363 mL
	100 mM	0.0172 mL	0.0858 mL	0.1716 mL	0.4291 mL

HeE1-2Tyr Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HeE1-2Tyr2245195-67-7Dengue virusFlavivirusSARS-CoVDENVSARS coronavirusRdRpflavivirusSARS-CoV-2WestNileDengueInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

HeE1-2Tyr

Customer Review

HeE1-2Tyr Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

HeE1-2Tyr Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

HeE1-2Tyr Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report