2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. Hemopressin(rat)

Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models.

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Custom Peptide Synthesis

Hemopressin(rat) Chemical Structure

Hemopressin(rat) Chemical Structure

CAS No. : 568588-77-2

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1 mg USD 55 In-stock
5 mg USD 140 In-stock
10 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Hemopressin(rat):

Hemopressin(rat) Related Antibodies

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Description

Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models[1][2].

In Vivo

Hemopressin(rat) causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE)[1].
Oral administration of Hemopressin(rat) inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin(rat) treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1088.26

Formula

C53H77N13O12
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His
Sequence Shortening

PVNFKFLSH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (91.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9189 mL 4.5945 mL 9.1890 mL
5 mM 0.1838 mL 0.9189 mL 1.8378 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9189 mL 4.5945 mL 9.1890 mL 22.9725 mL
5 mM 0.1838 mL 0.9189 mL 1.8378 mL 4.5945 mL
10 mM 0.0919 mL 0.4594 mL 0.9189 mL 2.2972 mL
15 mM 0.0613 mL 0.3063 mL 0.6126 mL 1.5315 mL
20 mM 0.0459 mL 0.2297 mL 0.4594 mL 1.1486 mL
25 mM 0.0368 mL 0.1838 mL 0.3676 mL 0.9189 mL
30 mM 0.0306 mL 0.1531 mL 0.3063 mL 0.7657 mL
40 mM 0.0230 mL 0.1149 mL 0.2297 mL 0.5743 mL
50 mM 0.0184 mL 0.0919 mL 0.1838 mL 0.4594 mL
60 mM 0.0153 mL 0.0766 mL 0.1531 mL 0.3829 mL
80 mM 0.0115 mL 0.0574 mL 0.1149 mL 0.2872 mL
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Hemopressin(rat) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hemopressin(rat)568588-77-2Cannabinoid ReceptorInhibitorinhibitorinhibit

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