Hemopressin(rat) 

Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models^[1][2].

Hemopressin(rat) causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE)^[1].
Oral administration of Hemopressin(rat) inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin(rat) treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1088.26

C₅₃H₇₇N₁₃O₁₂

568588-77-2

Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His

PVNFKFLSH

OC([C@H](CC1=CN=CN1)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@@H]2CCCN2)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O

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• [1]. Camila Squarzoni Dale, et al. Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin. em Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:105-6.  [Content Brief]

  [2]. Elaine F Toniolo, et al. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides. 2014 Jun;56:125-31.  [Content Brief]