2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. HER2-IN-15

HER2-IN-15 (Compound 1) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-15 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

HER2-IN-15 Chemical Structure

HER2-IN-15 Chemical Structure

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HER2-IN-15 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

HER2-IN-15 (Compound 1) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-15 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC)[1].

IC50 & Target

Her2 exon 20 YVMA insertion

<200 nM (IC50)

Molecular Weight

523.59

Formula

C28H29N9O2
SMILES

CC1=CC(NC2=NC=NN3C=CC(C4CN(C4)C(/C=C/CN(C)C)=O)=C23)=CC=C1OC5=CC6=NC=NN6C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (95.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9099 mL 9.5495 mL 19.0989 mL
5 mM 0.3820 mL 1.9099 mL 3.8198 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9099 mL 9.5495 mL 19.0989 mL 47.7473 mL
5 mM 0.3820 mL 1.9099 mL 3.8198 mL 9.5495 mL
10 mM 0.1910 mL 0.9549 mL 1.9099 mL 4.7747 mL
15 mM 0.1273 mL 0.6366 mL 1.2733 mL 3.1832 mL
20 mM 0.0955 mL 0.4775 mL 0.9549 mL 2.3874 mL
25 mM 0.0764 mL 0.3820 mL 0.7640 mL 1.9099 mL
30 mM 0.0637 mL 0.3183 mL 0.6366 mL 1.5916 mL
40 mM 0.0477 mL 0.2387 mL 0.4775 mL 1.1937 mL
50 mM 0.0382 mL 0.1910 mL 0.3820 mL 0.9549 mL
60 mM 0.0318 mL 0.1592 mL 0.3183 mL 0.7958 mL
80 mM 0.0239 mL 0.1194 mL 0.2387 mL 0.5968 mL
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HER2-IN-15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HER2-IN-15EGFREpidermal growth factor receptorErbB-1HER1non-small-cell lung cancerNSCLCepidermal growth factor receptorBaF3Inhibitorinhibitorinhibit

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