Rafutrombopag (tautomerism) (Synonyms: Hetrombopag (tautomerism); SHR-8735 (tautomerism))

Cat. No.: HY-122620 Purity: 98.33%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Rafutrombopag (tautomerism) is a potent thrombopoietin receptor agonist. Rafutrombopag (tautomerism) is efficacious and well tolerated with a manageable safety profile. Rafutrombopag (tautomerism) has the potential for the research of immune thrombocytopenia.

For research use only. We do not sell to patients.

Rafutrombopag (tautomerism) Chemical Structure

CAS No. : 2114365-78-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Clinical Trial

Molecular Weight

458.47

Formula

C₂₅H₂₂N₄O₅

CAS No.

2114365-78-3

Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C(C1=CC=C(C2=C(O)C(/N=N/C3C(N(C4=CC=C5C(CCCC5)=C4)N=C3C)=O)=CC=C2)O1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (21.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 6.25 mg/mL (13.63 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1812 mL	10.9058 mL	21.8117 mL
5 mM	0.4362 mL	2.1812 mL	4.3623 mL
10 mM	0.2181 mL	1.0906 mL	2.1812 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.33%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (250 KB) HNMR (291 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Mei H, et al. A multicenter, randomized phase III trial of hetrombopag: a novel thrombopoietin receptor agonist for the treatment of immune thrombocytopenia. J Hematol Oncol. 2021;14(1):37. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / DMSO	1 mM	2.1812 mL	10.9058 mL	21.8117 mL	54.5292 mL
	5 mM	0.4362 mL	2.1812 mL	4.3623 mL	10.9058 mL
	10 mM	0.2181 mL	1.0906 mL	2.1812 mL	5.4529 mL
DMSO	15 mM	0.1454 mL	0.7271 mL	1.4541 mL	3.6353 mL
DMSO	20 mM	0.1091 mL	0.5453 mL	1.0906 mL	2.7265 mL

Rafutrombopag (tautomerism) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rafutrombopag (tautomerism)2114365-78-3Hetrombopag (tautomerism) SHR-8735 (tautomerism)Thrombopoietin Receptorthrombopoietin receptorefficaciousimmune thrombocytopeniasafetyInhibitorinhibitorinhibit

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Rafutrombopag (tautomerism) (Synonyms: Hetrombopag (tautomerism); SHR-8735 (tautomerism))

Customer Review

Other Forms of Rafutrombopag (tautomerism):

Rafutrombopag (tautomerism) Related Antibodies

Featured Recommendations

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•Related Small Molecules:

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Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Rafutrombopag (tautomerism) Related Classifications

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