2. Metabolic Enzyme/Protease Apoptosis
  3. Thrombin Apoptosis
  4. Hirudin

Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others.

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Hirudin Chemical Structure

Hirudin Chemical Structure

CAS No. : 8001-27-2

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Based on 1 publication(s) in Google Scholar

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Hirudin Related Antibodies

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Description

Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others[1].

In Vitro

Hirudin inhibits the activity of thrombin, deprives the ability of thrombin to cleave fibrinogen, prevents the formation of fibrin and the cross-linking polymerization process of fibrin monomer in internal and external coagulation pathway[1].
Hirudin reduces cell apoptosis of human microvascular endothelial cells (HMVECs) and suppresses the expression of p-JAK2 via antagonizing thrombin[1].
Hirudin inhibits VEGF-Notch pathway and cell proliferation of HMVECs at high doses[1].
Hirudin (3-10 mg/mL) reverses the abnormal proliferation and fibrosis in HK-2 cells caused by TGF-β1[1].
Hirudin depresses the myocardial fibroblasts induced by angiotensin II by dose-dependently inhibits oxidative stress, regulates fibrosis-related factors, and represses the ERK1/2 pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hirudin Related Antibodies
In Vivo

Hirudin increases the viability of rat random skin flap and reduces inflammatory responses[1].
Hirudin promotes the wound healing in SD rats after laser surgery[1].
Hirudin (10 and 15 mg/kg; i.g. once daily for 21 days) improves renal interstitial fibrosis to reduce renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male balb/c mice with underwent unilateral ureteral ligation (UUO)[2]
Dosage: 10 and 15 mg/kg
Administration: Oral gavage; 10 and 15 mg/kg, once daily for 21 days
Result: Reduced renal damages and suppressed the upregulation of α-SMA, collagen deposition in UUO mice. Increased the level of fibrosis (collagen-I, FN, α-SMA), N-cad, slug and E-cad in UUO mice. Decreased the level of IL-1β, IL-6 and TNF-α, apoptosis of renal tubular cells in UUO mice. Decreased the expression of inflammatory factors, the occurrence of EMT, the incidence of fibrosis and the apoptosis of TGF-β-induced renal tubular epithelial cell.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

Structure Classification
Initial Source

leech
Shipping

Shipping with dry ice.
Storage

-80°C
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (240 KB)

Handling Instructions (2659 KB)
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Hirudin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hirudin8001-27-2ThrombinApoptosisanticoagulantanti-thromboticJAK2HMVECVEGFHK-2ERK1/2angiotensin IIUOOratInhibitorinhibitorinhibit

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