HIV-1 capsid inhibitor 1 

HIV-1 capsid inhibitor 1 is a potent HIV-1 Capsid inhibitor with an EC₅₀ value of 3.13 µM. HIV-1 capsid inhibitor 1 shows antiviral activities^[1].

HIV-1 capsid inhibitor 1 (compound 6a-9) shows anti-HIV activity in TZM-bl cells with an EC₅₀ value of 3.13 µM and an CC₅₀ value of >16.48 µM^[1].
HIV-1 capsid inhibitor 1 shows antiviral activities in the early and late event of the HIV-1 NL4-3 lifecycle with IC₅₀s of 8.18, 0.32 µM, respectively^[1].
HIV-1 capsid inhibitor 1 shows metabolic stability in human liver microsomes and plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

606.65

C₃₄H₃₁FN₆O₄

2396382-78-6

COC1=CC=C(C=C1)N(C)C([C@@H](NC(CN2C=C(N=N2)C3=CC=CC=C3NC(C4=CC=CC=C4F)=O)=O)CC5=CC=CC=C5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sun L, et al. Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities. Eur J Med Chem. 2020 Mar 15;190:112085.  [Content Brief]