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  4. HIV-1 inhibitor-15

HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability.

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HIV-1 inhibitor-15 Chemical Structure

HIV-1 inhibitor-15 Chemical Structure

CAS No. : 2757182-99-1

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HIV-1 inhibitor-15 Related Antibodies

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Description

HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].

IC50 & Target[1]

HIV-1 (WT)

1.7 nM (EC50)

HIV-1 (L100I)

4 nM (EC50)

HIV-1 (K103N)

2 nM (EC50)

HIV-1 (Y181C)

6 nM (EC50)

HIV-1 (E138K)

9 nM (EC50)

Cellular Effect
Cell Line Type Value Description References
MT4 CC50
6 μM
Compound: 9d
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
[PMID: 35073089]
Molecular Weight

392.46

Formula

C24H20N6
CAS No.
SMILES

N#CC1=CC=C(NC2=NC=CC(NC3=C(C)C=C(C4=CC=NC=C4)C=C3C)=N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-152757182-99-1HIVHuman immunodeficiency virusAnti-HIVAIDSHIV-1 K103NHIV-1 E138KHIV-1 Y181CHIV-1 L100IInhibitorinhibitorinhibit

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HY-144122
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