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  4. HIV-1 inhibitor-16

HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity.

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HIV-1 inhibitor-16 Chemical Structure

HIV-1 inhibitor-16 Chemical Structure

CAS No. : 2719675-72-4

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HIV-1 inhibitor-16 Related Antibodies

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Description

HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity[1].

IC50 & Target[1]

HIV-1 (WT)

1.3 nM (EC50)

HIV-1 (K103N)

5.4 nM (EC50)

HIV-1 (E138K)

9.2 nM (EC50)

HIV-1 (Y181C)

22 nM (EC50)

HIV-1 (L100I)

35 mM (EC50)

Cellular Effect
Cell Line Type Value Description References
MT4 CC50
264 μM
Compound: 7a
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
[PMID: 35073089]
Molecular Weight

414.41

Formula

C23H16F2N6
CAS No.
SMILES

N#CC1=CC=C(NC2=NC=C(C)C(NC3=C(F)C=C(C4=CC=NC=C4)C=C3F)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-162719675-72-4HIVHuman immunodeficiency virusAnti-HIVAIDSHIV-1 K103NHIV-1 E138KHIV-1 Y181CHIV-1 L100IInhibitorinhibitorinhibit

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HIV-1 inhibitor-16
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HY-144123
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