2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-25

HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS.

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HIV-1 inhibitor-25 Chemical Structure

HIV-1 inhibitor-25 Chemical Structure

CAS No. : 2475658-74-1

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HIV-1 inhibitor-25 Related Antibodies

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Description

HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS[1].

IC50 & Target[1]

HIV (IIIB)

13.6 nM (EC50)

HIV-1 (L100I)

1.2458 ± 0 μM (EC50)

HIV-1 (K103N)

0.4383 ± 0 μM (EC50)

HIV-1 (Y181C)

0.5075 ± 0 μM (EC50)

HIV-1 (Y188L)

5.8136 ± 2 μM (EC50)

HIV-1 (E138K)

0.1961 ± 0 μM (EC50)

HIV-1 (F227L+V106A)

3.0683 ± 0 μM (EC50)

Cellular Effect
Cell Line Type Value Description References
MT4 CC50
33.13 μM
Compound: (R)-12a
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
[PMID: 32712537]
Molecular Weight

433.46

Formula

C26H19N5O2
CAS No.
SMILES

N#CC1=CC=C(C2=CC=C([C@H](C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3)O)C(OC)=C2)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-25 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-252475658-74-1HIVHuman immunodeficiency virusAnti-HIVAIDSReverse transcriptaseHIV-1 L100IHIV-1 K103 NHIV-1 Y181CHIV-1 Y188LHIV-1 E138KHIV-1 F227L+V106AMT-4 cellsInhibitorinhibitorinhibit

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HIV-1 inhibitor-25
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HY-146019A
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