HIV-1 inhibitor-43 

HIV-1 inhibitor-43 is a potent HIV-1 inhibitor with an EC₅₀ of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression^[1].

HIV-1 inhibitor-43 (compound 12) has anti-HIV-1 activity against HIV-1 reverse transcriptase with IC₅₀s of 83±8 nM, 73±8 nM, 61±6 nM and 76±8 nM for HIV-1 WT, K103N, Y181I and K103N-Y181I, respectively^[1].
HIV-1 inhibitor-43 (1, 5 and 25 nM) causes 100% reduction of HIV-1 RNA and protein p24 at 25 nM in C8166 cells infected with a WT strain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

468.95

C₂₄H₂₁ClN₂O₄S

2493426-43-8

O=C(C(N1)=C(S(=O)(C2=CC(C)=CC(C)=C2)=O)C3=C1C=CC(Cl)=C3)NCC4=CC=CC=C4O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nalli M, et al. New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains. Eur J Med Chem. 2020 Dec 15;208:112696.  [Content Brief]