2. Anti-infection
  3. HIV
  4. HIV-1 protease-IN-1

HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of HIV-1 protease with an IC50 of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC50 value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC50 value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC50 value of 8.23 nM against C-HIV strain Indie[1].

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HIV-1 protease-IN-1 Chemical Structure

HIV-1 protease-IN-1 Chemical Structure

CAS No. : 2765293-30-7

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HIV-1 protease-IN-1 Related Antibodies

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Description

HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of HIV-1 protease with an IC50 of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC50 value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC50 value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC50 value of 8.23 nM against C-HIV strain Indie[1].

Cellular Effect
Cell Line Type Value Description References
HEK-293T CC50
> 200 μM
Compound: 1e
Cytotoxicity against human HEK-293T cells after 24 hrs by CCK-8 assay
Cytotoxicity against human HEK-293T cells after 24 hrs by CCK-8 assay
[PMID: 35278855]
Molecular Weight

505.63

Formula

C25H35N3O6S
CAS No.
SMILES

O=C(N[C@H]([C@@H](CN(S(C1=CC=C(C=C1)O)(=O)=O)CC(C)C)O)CC2=CC=CC=C2)[C@@H]3COCCN3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 protease-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 protease-IN-12765293-30-7HIVHuman immunodeficiency virusHIV-1 proteaseantiviralB-HIVZM246Inhibitorinhibitorinhibit

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