HJC0149

Cat. No.: HY-116278: FAQs
Data Sheet Handling Instructions

Molarity Calculator

HJC0149 is a potent and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3).

For research use only. We do not sell to patients.

HJC0149 Chemical Structure

CAS No. : 1430330-65-6

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All STAT Isoform Specific Products:

View All Isoforms

STAT3 STAT5 STAT6 STAT1

Biological Activity
Purity & Documentation
References
Customer Review

Description

HJC0149 is a potent and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
ASPC1	IC₅₀	1.92 μM Compound: 1, HJC0149	Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 24904966]
ASPC1	IC₅₀	1.92 μM Compound: 12	CYtotoxicity against human AsPC1 cells by MTS assay CYtotoxicity against human AsPC1 cells by MTS assay	[PMID: 23416191]
MCF7	IC₅₀	0.91 μM Compound: 1, HJC0149	Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 24904966]
MCF7	IC₅₀	0.91 μM Compound: 12	CYtotoxicity against ER-positive human MCF7 cells by MTS assay CYtotoxicity against ER-positive human MCF7 cells by MTS assay	[PMID: 23416191]
MDA-MB-231	IC₅₀	1.64 μM Compound: 1, HJC0149	Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 24904966]
MDA-MB-231	IC₅₀	1.64 μM Compound: 12	CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay	[PMID: 23416191]
PANC-1	IC₅₀	2.34 μM Compound: 1, HJC0149	Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 24904966]
PANC-1	IC₅₀	2.34 μM Compound: 12	CYtotoxicity against human PANC1 cells by MTS assay CYtotoxicity against human PANC1 cells by MTS assay	[PMID: 23416191]

Molecular Weight

335.76

Formula

C₁₅H₁₀ClNO₄S

CAS No.

1430330-65-6

SMILES

OC1=C(C=C(C=C1)Cl)C(NC2=CC3=C(C=C2)C=CS3(=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen H, et al. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur J Med Chem. 2014;82:195-203. [Content Brief]

HJC0149 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJC01491430330-65-6HJC 0149HJC-0149STATAnticancer agentsBreast cancerOral bioavailabilityPancreatic cancerSTAT3 inhibitorsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks