2. Cell Cycle/DNA Damage
  3. RAD51
  4. Homologous recombination-IN-1

Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination.

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Homologous recombination-IN-1 Chemical Structure

Homologous recombination-IN-1 Chemical Structure

CAS No. : 391889-85-3

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Based on 1 publication(s) in Google Scholar

Homologous recombination-IN-1 Related Antibodies

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Description

Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination[1].

In Vitro

Homologous recombination-IN-1 (10-40 μM; 5 h) reduces cell homologous recombination in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Homologous recombination-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: BxPC3 cells
Concentration: 10-40 μM
Incubation Time: 5 hours
Result: Led to homologous recombination inhibition with an EC50 value of 18.4 μM.
Molecular Weight

485.96

Formula

C28H24ClN3O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC2=C(C(C3=CC=CC=C3)=C1C4=NN(C(C4)C5=CC=C(C=C5)OC)C(CC)=O)C=C(Cl)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (102.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0578 mL 10.2889 mL 20.5778 mL
5 mM 0.4116 mL 2.0578 mL 4.1156 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0578 mL 10.2889 mL 20.5778 mL 51.4446 mL
5 mM 0.4116 mL 2.0578 mL 4.1156 mL 10.2889 mL
10 mM 0.2058 mL 1.0289 mL 2.0578 mL 5.1445 mL
15 mM 0.1372 mL 0.6859 mL 1.3719 mL 3.4296 mL
20 mM 0.1029 mL 0.5144 mL 1.0289 mL 2.5722 mL
25 mM 0.0823 mL 0.4116 mL 0.8231 mL 2.0578 mL
30 mM 0.0686 mL 0.3430 mL 0.6859 mL 1.7148 mL
40 mM 0.0514 mL 0.2572 mL 0.5144 mL 1.2861 mL
50 mM 0.0412 mL 0.2058 mL 0.4116 mL 1.0289 mL
60 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8574 mL
80 mM 0.0257 mL 0.1286 mL 0.2572 mL 0.6431 mL
100 mM 0.0206 mL 0.1029 mL 0.2058 mL 0.5144 mL
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Homologous recombination-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homologous recombination-IN-1391889-85-3RAD51homologous recombinationBxPC3Inhibitorinhibitorinhibit

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