HS56

Cat. No.: HY-123983: FAQs
Data Sheet Handling Instructions

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HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with K_i values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.

For research use only. We do not sell to patients.

HS56 Chemical Structure

CAS No. : 922050-57-5

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PIM1 PIM2 PIM3

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

PIM3

0.208 μM (Ki)

PIM1

2.94 μM (Ki)

PIM2

＞100 μM (Ki)

In Vitro

HS56 (50 μM; 16 h) delays force onset, decreases contractile force, and reduces LC20 phosphorylation in excised rat caudal arterial VSM tissues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	VSM tissues
Concentration:	50 μM
Incubation Time:	16 hours
Result:	Modulated LC20 phosphorylation in VSM tissues.

In Vivo

HS56 (10 and 20 mg/kg; i.v.; single injection) decreases blood pressure (BP) in spontaneously hypertensive mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Spontaneously hypertensive renin transgene and wild-type (WT) mice^[1]
Dosage:	10 and 20 mg/kg
Administration:	Intravenous injection, single injection
Result:	Induced dose-dependent decreases in systolic blood pressure.

Molecular Weight

317.75

Formula

C₁₃H₈ClN₅OS

CAS No.

922050-57-5

SMILES

N#CCSC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Carlson DA, et, al. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol. 2018 Oct 18;25(10):1195-1207.e32. [Content Brief]

HS56 Related Classifications

Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS56922050-57-5HS 56HS-56PimDAPKPim kinasesDeath associated protein kinaseLC20phosphorylationsmooth muscleblood pressurehypertensionInhibitorinhibitorinhibit

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