2. Metabolic Enzyme/Protease
  3. 17β-HSD
  4. HSD17B13-IN-43

HSD17B13-IN-43 (11) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research.

For research use only. We do not sell to patients.

HSD17B13-IN-43 Chemical Structure

HSD17B13-IN-43 Chemical Structure

CAS No. : 2770246-11-0

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Based on 1 publication(s) in Google Scholar

HSD17B13-IN-43 Related Antibodies

Top Publications Citing Use of Products

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17β-HSD1 17β-HSD2 17β-HSD5/AKR1C3

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Description

HSD17B13-IN-43 (11) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research[1].

Molecular Weight

508.28

Formula

C23H14Cl2F3N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(NC(C3=CC(Cl)=C(O)C(Cl)=C3)=O)C=CC=C2N=CN1CC4=CC=CC(C(F)(F)F)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (19.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9674 mL 9.8371 mL 19.6742 mL
5 mM 0.3935 mL 1.9674 mL 3.9348 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9674 mL 9.8371 mL 19.6742 mL 49.1855 mL
5 mM 0.3935 mL 1.9674 mL 3.9348 mL 9.8371 mL
10 mM 0.1967 mL 0.9837 mL 1.9674 mL 4.9185 mL
15 mM 0.1312 mL 0.6558 mL 1.3116 mL 3.2790 mL
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HSD17B13-IN-43 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSD17B13-IN-432770246-11-017β-HSD17beta-HSD17β-hydroxysteroid dehydrogenases17 beta-hydroxysteroid dehydrogenaseNAFLDNonalcoholic fatty liver diseaseInhibitorinhibitorinhibit

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