2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Bcl-2 Family Apoptosis
  4. HSP70-IN-6

HSP70-IN-6 (Compound JL-15) is an inhibitor of Hsp70-Bim protein-protein interaction (PPI) (IC50: 70 nM). HSP70-IN-6 induces apoptosis in chronic myeloid leukemia (CML) cells, with EC50s of 0.43 μM(BV173), 0.88 μM (K562), 0.19 μM (K562-R3).

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HSP70-IN-6 Chemical Structure

HSP70-IN-6 Chemical Structure

CAS No. : 3048341-44-9

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HSP70-IN-6 Related Antibodies

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Description

HSP70-IN-6 (Compound JL-15) is an inhibitor of Hsp70-Bim protein-protein interaction (PPI) (IC50: 70 nM). HSP70-IN-6 induces apoptosis in chronic myeloid leukemia (CML) cells, with EC50s of 0.43 μM(BV173), 0.88 μM (K562), 0.19 μM (K562-R3)[1].

IC50 & Target[1]

HSP70

 

Bim

 

Molecular Weight

476.01

Formula

C28H30ClN3O2
CAS No.
SMILES

OC1=C(C(NCCN2CCCCC2)=CC(C3=CC=C(C=C3)OC4=CC(C)=C(C(C)=C4)Cl)=C1)C#N
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HSP70-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP70-IN-63048341-44-9HSPBcl-2 FamilyApoptosisHeat shock proteinschronic myeloid leukemiaCMLInhibitorinhibitorinhibit

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