2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. HSP90-IN-19

HSP90-IN-19 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC50 value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation.

For research use only. We do not sell to patients.

HSP90-IN-19 Chemical Structure

HSP90-IN-19 Chemical Structure

CAS No. : 2927442-48-4

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HSP90-IN-19 Related Antibodies

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Description

HSP90-IN-19 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC50 value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation[1].

IC50 & Target

IC50: 0.27 μM (Hsp90); ＞40 μM (MCF-7); ＞40 (SW480); ＞40 μM (A549); 16.95 μM (HL60); ＞40 μM (SMMC-7721)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 40 μM
Compound: 31
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
HL-60 IC50
16.95 μM
Compound: 31
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
MCF7 IC50
> 40 μM
Compound: 31
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
SMMC-7721 IC50
> 40 μM
Compound: 31
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
SW480 IC50
> 40 μM
Compound: 31
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
In Vitro

HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC50 value of 0.27 μM[1].
HSP90-IN-19 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) has antiproliferative activity against MCF-7, SW480, A549, HL60 and SMMC-7721 with IC50 values of ＞40 μM, ＞40 μM, ＞40 μM, 16.95 μM and ＞40 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSP90-IN-19 Related Antibodies
Molecular Weight

498.61

Formula

C29H38O7
CAS No.
SMILES

C/C(C)=C\CC[C@]1(CC=C(C2=C([C@@H]1/C=C/OC(/C=C(C)/C)=O)C=C(O2)C)COC(CCC(O)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSP90-IN-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP90-IN-192927442-48-4HSPHeat shock proteinsheat shock protein 90 (Hsp90)viral infectionneurodegenerative diseaseinflammationInhibitorinhibitorinhibit

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