2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. HSP90-IN-33

HSP90-IN-33 (compound 24e) is a potent Hsp90 inhibitor with Kd values of ≥200, 7.3 µM for Hsp90α, Hsp90β, respectively. HSP90-IN-33 induces apoptosis and cell cycle arrest at G0/G1 phase. HSP90-IN-33 decreases the protein expression of ERα, CDK4 and Akt.

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HSP90-IN-33 Chemical Structure

HSP90-IN-33 Chemical Structure

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HSP90-IN-33 Related Antibodies

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Description

HSP90-IN-33 (compound 24e) is a potent Hsp90 inhibitor with Kd values of ≥200, 7.3 µM for Hsp90α, Hsp90β, respectively. HSP90-IN-33 induces apoptosis and cell cycle arrest at G0/G1 phase. HSP90-IN-33 decreases the protein expression of ERα, CDK4 and Akt[1].

IC50 & Target[1]

HSP90α

≥200 μM (EC50)

HSP90β

7.3 μM (EC50)

Molecular Weight

450.36

Formula

C21H25Cl2N5O2
SMILES

O=C(C1=C(Cl)C(Cl)=C(C)N1)NC2=CC=C(C(N)=O)C=C2N3CC4(CN(C)CC4)CC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSP90-IN-33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP90-IN-33HSPApoptosisHeat shock proteinsMCF-7 cellsapoptosisG0/G1 phaseERαCDK4AktInhibitorinhibitorinhibit

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