Human PD-L1 inhibitor IV

Cat. No.: HY-P2477 Purity: 99.68%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a K_d value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Human PD-L1 inhibitor IV Chemical Structure

CAS No. : 2135542-83-3

Size	Price	Stock	Quantity
5 mg	USD 220	In-stock	Estimated Time of Arrival: April 8
10 mg	USD 330	In-stock	Estimated Time of Arrival: April 8
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a K_d value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1^[1].

IC₅₀ & Target

Kd: 1.38 μM (Human PD-1 protein)^[1]

Molecular Weight

1856.90

Formula

C₈₀H₁₁₃N₂₅O₂₇

CAS No.

2135542-83-3

Appearance

Solid

Color

White to off-white

Sequence Shortening

GNWDYNSQRAQLYNQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (26.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.5385 mL	2.6927 mL	5.3853 mL
5 mM	0.1077 mL	0.5385 mL	1.0771 mL
10 mM	0.0539 mL	0.2693 mL	0.5385 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) LCMS (248 KB)

Handling Instructions (2659 KB)

References

[1]. Qiao Li, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.5385 mL	2.6927 mL	5.3853 mL	13.4633 mL
	5 mM	0.1077 mL	0.5385 mL	1.0771 mL	2.6927 mL
	10 mM	0.0539 mL	0.2693 mL	0.5385 mL	1.3463 mL
	15 mM	0.0359 mL	0.1795 mL	0.3590 mL	0.8976 mL
	20 mM	0.0269 mL	0.1346 mL	0.2693 mL	0.6732 mL
	25 mM	0.0215 mL	0.1077 mL	0.2154 mL	0.5385 mL