2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Human PD-L1 inhibitor IV

Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a Kd value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Human PD-L1 inhibitor IV Chemical Structure

Human PD-L1 inhibitor IV Chemical Structure

CAS No. : 2135542-83-3

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Based on 1 publication(s) in Google Scholar

Human PD-L1 inhibitor IV Related Antibodies

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Description

Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a Kd value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1[1].

IC50 & Target

Kd: 1.38 μM (Human PD-1 protein)[1]
Molecular Weight

1856.90

Formula

C80H113N25O27
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

GNWDYNSQRAQLYNQ
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (26.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5385 mL 2.6927 mL 5.3853 mL
5 mM 0.1077 mL 0.5385 mL 1.0771 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.68%

SDS (252 KB)

COA (248 KB) LCMS (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5385 mL 2.6927 mL 5.3853 mL 13.4633 mL
5 mM 0.1077 mL 0.5385 mL 1.0771 mL 2.6927 mL
10 mM 0.0539 mL 0.2693 mL 0.5385 mL 1.3463 mL
15 mM 0.0359 mL 0.1795 mL 0.3590 mL 0.8976 mL
20 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.6732 mL
25 mM 0.0215 mL 0.1077 mL 0.2154 mL 0.5385 mL
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Human PD-L1 inhibitor IV Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Human PD-L1 inhibitor IV2135542-83-3PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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