2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK JAK/STAT Signaling PI3K/Akt/mTOR Apoptosis
  3. HSP EGFR Akt Survivin
  4. HVH-2930

HVH-2930 is an inhibitor for heat shock protein 90 (HSP90). HVH-2930 inhibits cell viability of BT474 (Trastuzumab (HY-P9907) sensitive) and JIMT-1 (Trastuzumab (HY-P9907) resistant), with IC50 of 6.86 μM and 4.42 μM, through downregulation of HSP90 clients HER2, p-HER2, AKT, p-AKT, cyclin D1 and survivin. HVH-2930 exhibits antitumor efficacy in mouse models. HVH-2930 exhibits good pharmacokinetic characteristics in mice.

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HVH-2930 Chemical Structure

HVH-2930 Chemical Structure

CAS No. : 3034605-72-3

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HVH-2930 Related Antibodies

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Description

HVH-2930 is an inhibitor for heat shock protein 90 (HSP90). HVH-2930 inhibits cell viability of BT474 (Trastuzumab (HY-P9907) sensitive) and JIMT-1 (Trastuzumab (HY-P9907) resistant), with IC50 of 6.86 μM and 4.42 μM, through downregulation of HSP90 clients HER2, p-HER2, AKT, p-AKT, cyclin D1 and survivin. HVH-2930 exhibits antitumor efficacy in mouse models. HVH-2930 exhibits good pharmacokinetic characteristics in mice[1].

Molecular Weight

488.62

Formula

C29H36N4O3
CAS No.
SMILES

O=C(C1=C(OC)C(C=CC(C)(C)O2)=C2C=C1)NC3=CC4=C(C=C3)C(C)=NN4CCC5CCN(C)CC5
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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HVH-2930 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HVH-29303034605-72-3HVH2930HVH 2930HSPEGFRAktSurvivinHeat shock proteinsEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BBALB/c mouseBT474JIMT-1trastuzumabInhibitorinhibitorinhibit

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