2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Hydrocortisone hemisuccinate sodium

Hydrocortisone hemisuccinate sodium  (Synonyms: Hydrocortisone 21-hemisuccinate sodium)

Cat. No.: HY-B1402B Purity: 99.66%
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Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC).

For research use only. We do not sell to patients.

Hydrocortisone hemisuccinate sodium Chemical Structure

Hydrocortisone hemisuccinate sodium Chemical Structure

CAS No. : 125-04-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Hydrocortisone hemisuccinate sodium:

Hydrocortisone hemisuccinate sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Hydrocortisone hemisuccinate sodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC)[1].

In Vitro

Hydrocortisone hemisuccinate sodium inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3].
Hydrocortisone hemisuccinate sodium (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrocortisone hemisuccinate sodium Related Antibodies
In Vivo

Hydrocortisone hemisuccinate sodium (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2]
Dosage: 30 mg/kg
Administration: P.o. twice daily for 5 days
Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight.
Molecular Weight

484.51

Formula

C25H33NaO8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](C(COC(CCC(O[Na])=O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (361.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (206.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0639 mL 10.3197 mL 20.6394 mL
5 mM 0.4128 mL 2.0639 mL 4.1279 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.66%

SDS (393 KB)

COA (250 KB) HNMR (306 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.0639 mL 10.3197 mL 20.6394 mL 51.5985 mL
5 mM 0.4128 mL 2.0639 mL 4.1279 mL 10.3197 mL
10 mM 0.2064 mL 1.0320 mL 2.0639 mL 5.1599 mL
15 mM 0.1376 mL 0.6880 mL 1.3760 mL 3.4399 mL
20 mM 0.1032 mL 0.5160 mL 1.0320 mL 2.5799 mL
25 mM 0.0826 mL 0.4128 mL 0.8256 mL 2.0639 mL
30 mM 0.0688 mL 0.3440 mL 0.6880 mL 1.7200 mL
40 mM 0.0516 mL 0.2580 mL 0.5160 mL 1.2900 mL
50 mM 0.0413 mL 0.2064 mL 0.4128 mL 1.0320 mL
60 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8600 mL
80 mM 0.0258 mL 0.1290 mL 0.2580 mL 0.6450 mL
100 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.5160 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Hydrocortisone hemisuccinate sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrocortisone hemisuccinate125-04-2Hydrocortisone 21-hemisuccinateGlucocorticoid ReceptorHydrocortisone hemisuccinate sodiumGlucocorticoidUlcerative colitisInhibitorinhibitorinhibit

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