2. PROTAC
  3. PROTAC Linkers
  4. Hydroxy-PEG3-acid

Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Hydroxy-PEG3-acid Chemical Structure

Hydroxy-PEG3-acid Chemical Structure

CAS No. : 518044-49-0

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250 mg USD 60 In-stock
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Based on 1 publication(s) in Google Scholar

Hydroxy-PEG3-acid Related Antibodies

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Description

Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydroxy-PEG3-acid Related Antibodies
Molecular Weight

222.24

Formula

C9H18O6
CAS No.
Appearance

Liquid (Density: 1.180±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (449.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4996 mL 22.4982 mL 44.9964 mL
5 mM 0.8999 mL 4.4996 mL 8.9993 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (240 KB) HNMR (128 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4996 mL 22.4982 mL 44.9964 mL 112.4910 mL
5 mM 0.8999 mL 4.4996 mL 8.9993 mL 22.4982 mL
10 mM 0.4500 mL 2.2498 mL 4.4996 mL 11.2491 mL
15 mM 0.3000 mL 1.4999 mL 2.9998 mL 7.4994 mL
20 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
25 mM 0.1800 mL 0.8999 mL 1.7999 mL 4.4996 mL
30 mM 0.1500 mL 0.7499 mL 1.4999 mL 3.7497 mL
40 mM 0.1125 mL 0.5625 mL 1.1249 mL 2.8123 mL
50 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
60 mM 0.0750 mL 0.3750 mL 0.7499 mL 1.8748 mL
80 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4061 mL
100 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL
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Hydroxy-PEG3-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxy-PEG3-acid518044-49-0PROTAC LinkersInhibitorinhibitorinhibit

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