Hydroxyevodiamine (Synonyms: Rhetsinine)

Cat. No.: HY-N2494: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC₅₀ value of 24.1 μM.

For research use only. We do not sell to patients.

Hydroxyevodiamine Chemical Structure

CAS No. : 1238-43-3

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC₅₀ value of 24.1 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	< 0.003 μM Compound: 10j	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
A549	IC₅₀	0.084 μM Compound: 1b	Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK8 assay	[PMID: 32292547]
HCT-116	GI₅₀	< 0.003 μM Compound: 10j	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
HCT-116	IC₅₀	0.055 μM Compound: 1b	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CCK8 assay	[PMID: 32292547]
MCF7	IC₅₀	0.27 μM Compound: 1b	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay	[PMID: 32292547]
MDA-MB-435	GI₅₀	< 0.003 μM Compound: 10j	Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]

Molecular Weight

319.36

Formula

C₁₉H₁₇N₃O₂

CAS No.

1238-43-3

SMILES

O=C1C2=C(N(C3(C4=C(CCN13)C5=C(C=CC=C5)N4)O)C)C=CC=C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. A Kato, et al. Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity. Phytomedicine. 2009 Mar;16(2-3):258-61. [Content Brief]

Hydroxyevodiamine Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxyevodiamine1238-43-3RhetsinineAldose ReductaseAldose reductaseDiabetic complicationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks