Hypericin-d₁₀

Name: Hypericin-d 10
Brand: MedChemExpress
SKU: HY-N0453S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0453S Purity: 95.32%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Hypericin-d₁₀ is the deuterium labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM.

For research use only. We do not sell to patients.

Hypericin-d<sub>10</sub> Chemical Structure

Hypericin-d₁₀ Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Hypericin-d₁₀:

Hypericin In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

514.50

Formula

C₃₀H₆D₁₀O₈

Unlabeled CAS

548-04-9

Appearance

Solid

Color

Brown to black

SMILES

O=C1C2=C(O)C([2H])=C(O)C3=C2C4=C(C5=C6C(O)=C([2H])C(C([2H])([2H])[2H])=C5C7=C4C1=C(O)C([2H])=C7C([2H])([2H])[2H])C8=C3C(O)=C([2H])C(O)=C8C6=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (485.91 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9436 mL	9.7182 mL	19.4363 mL
5 mM	0.3887 mL	1.9436 mL	3.8873 mL
10 mM	0.1944 mL	0.9718 mL	1.9436 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.32%

Select Batch:

Data Sheet (284 KB) SDS (393 KB)

COA (265 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34(3):221-41. [Content Brief]

[3]. Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62. [Content Brief]

[4]. Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21(4A):2649-55. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9436 mL	9.7182 mL	19.4363 mL	48.5909 mL
	5 mM	0.3887 mL	1.9436 mL	3.8873 mL	9.7182 mL
	10 mM	0.1944 mL	0.9718 mL	1.9436 mL	4.8591 mL
	15 mM	0.1296 mL	0.6479 mL	1.2958 mL	3.2394 mL
	20 mM	0.0972 mL	0.4859 mL	0.9718 mL	2.4295 mL
	25 mM	0.0777 mL	0.3887 mL	0.7775 mL	1.9436 mL
	30 mM	0.0648 mL	0.3239 mL	0.6479 mL	1.6197 mL
	40 mM	0.0486 mL	0.2430 mL	0.4859 mL	1.2148 mL
	50 mM	0.0389 mL	0.1944 mL	0.3887 mL	0.9718 mL
	60 mM	0.0324 mL	0.1620 mL	0.3239 mL	0.8098 mL
	80 mM	0.0243 mL	0.1215 mL	0.2430 mL	0.6074 mL
	100 mM	0.0194 mL	0.0972 mL	0.1944 mL	0.4859 mL