2. PI3K/Akt/mTOR NF-κB
  3. Akt NF-κB PI3K
  4. Hypoglycemic agent 3

Hypoglycemic agent 3 (Compound H26), a derivative of corosolic acid, exhibits lipid-lowering and significant hypoglycemic effects and can be used as a hypoglycemic agent. Hypoglycemic agent 3 inhibits insulin resistance by targeting MCCC1 and can be used in the study of type 2 diabetes.

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Hypoglycemic agent 3 Chemical Structure

Hypoglycemic agent 3 Chemical Structure

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Hypoglycemic agent 3 Related Antibodies

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Description

Hypoglycemic agent 3 (Compound H26), a derivative of corosolic acid, exhibits lipid-lowering and significant hypoglycemic effects and can be used as a hypoglycemic agent. Hypoglycemic agent 3 inhibits insulin resistance by targeting MCCC1 and can be used in the study of type 2 diabetes[1].

In Vitro

Hypoglycemic agent 3 (Compound H26) (40-320 μM; 24 h) shows no significant cytotoxicity in HepG2 cells[1].
Hypoglycemic agent 3 (20-40 μM) suppresses insulin resistance primarily by increasing MCCC1 in HepG2 cells[1].
Hypoglycemic agent 3 (20 μM; 1 h) significantly inhibits the increase in glucose production induced by glucosamine (18 mM; 18 h) (HY-B1125) in HepG2 cells[1].
Hypoglycemic agent 3 (2.5-20 μM; 1 h) can activate PI3K-AKT and inhibit NF-κB signaling pathway in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hypoglycemic agent 3 Related Antibodies

Western Blot Analysis[1]

Cell Line: HepG2
Concentration: 2.5, 10, 20 μM
Incubation Time: 1 h
Result: Ehanced the phosphorylation levels of KT and GSK3β.
Sgnificantly increased the expression of IκBα, suggesting that H26 may inhibit the activation of NF-κB.
Molecular Weight

529.75

Formula

C32H51NO5
SMILES

O=C(O)CNC([C@]12CC[C@@H](C)[C@H](C)[C@@]1([H])C3=CCC4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Hypoglycemic agent 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hypoglycemic agent 3Hypoglycemic agent3Hypoglycemic agent-3AktNF-κBPI3KPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBPhosphoinositide 3-kinaseType 2 diabetes mellitus (T2DM)HepG2 cellsanti-diabetic activityInhibitorinhibitorinhibit

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HY-170692
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