2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Autophagy
  3. CFTR Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy
  4. Glucosamine

Glucosamine  (Synonyms: D-Glucosamine; Chitosamine)

Cat. No.: HY-B1125 Purity: ≥98.0%
SDS COA Handling Instructions

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Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

For research use only. We do not sell to patients.

Glucosamine Chemical Structure

Glucosamine Chemical Structure

CAS No. : 3416-24-8

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5 mg USD 32 In-stock
10 mg USD 50 In-stock
25 mg USD 75 In-stock
50 mg USD 120 In-stock
100 mg USD 180 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of Glucosamine:

Glucosamine Related Antibodies

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Description

Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Glucosamine (D-Glucosamine) exhibits dose-dependent DPPH antioxidant activity[2].
Glucosamine treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3].
Glucosamine significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glucosamine Related Antibodies
Clinical Trial
Molecular Weight

179.17

Formula

C6H13NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (558.12 mM; ultrasonic and warming and heat to 60°C)

DMSO : 3.33 mg/mL (18.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5812 mL 27.9061 mL 55.8123 mL
5 mM 1.1162 mL 5.5812 mL 11.1625 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (279.06 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (247 KB) HNMR (113 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.5812 mL 27.9061 mL 55.8123 mL 139.5307 mL
5 mM 1.1162 mL 5.5812 mL 11.1625 mL 27.9061 mL
10 mM 0.5581 mL 2.7906 mL 5.5812 mL 13.9531 mL
15 mM 0.3721 mL 1.8604 mL 3.7208 mL 9.3020 mL
H2O 20 mM 0.2791 mL 1.3953 mL 2.7906 mL 6.9765 mL
25 mM 0.2232 mL 1.1162 mL 2.2325 mL 5.5812 mL
30 mM 0.1860 mL 0.9302 mL 1.8604 mL 4.6510 mL
40 mM 0.1395 mL 0.6977 mL 1.3953 mL 3.4883 mL
50 mM 0.1116 mL 0.5581 mL 1.1162 mL 2.7906 mL
60 mM 0.0930 mL 0.4651 mL 0.9302 mL 2.3255 mL
80 mM 0.0698 mL 0.3488 mL 0.6977 mL 1.7441 mL
100 mM 0.0558 mL 0.2791 mL 0.5581 mL 1.3953 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glucosamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucosamine3416-24-8D-Glucosamine ChitosamineCFTREndogenous MetaboliteReactive Oxygen SpeciesHIF/HIF Prolyl-HydroxylaseAutophagyCystic fibrosis transmembrane conductance regulatorHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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