2. PI3K/Akt/mTOR Apoptosis Autophagy
  3. mTOR Akt Apoptosis Autophagy PI3K
  4. HYS-072

HYS-072 is an orally active derivative of chrysin (HY-14589) with antitumor activity. HYS-072 induces apoptosis and autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway and suppresses tumor growth in vivo in xenograft models by modulating autophagy-related pathways. HYS-072 can be used in research on the treatment of triple-negative breast cancer.

For research use only. We do not sell to patients.

HYS-072 Chemical Structure

HYS-072 Chemical Structure

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HYS-072 Related Antibodies

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mTOR mTORC1 mTORC2

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Akt Akt1 Akt2 Akt3

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

HYS-072 is an orally active derivative of chrysin (HY-14589) with antitumor activity. HYS-072 induces apoptosis and autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway and suppresses tumor growth in vivo in xenograft models by modulating autophagy-related pathways. HYS-072 can be used in research on the treatment of triple-negative breast cancer.

Molecular Weight

458.51

Formula

C27H26N2O5
SMILES

CC1=CC=C(NC(NCCCCOC2=CC(O)=C3C(OC(C4=CC=CC=C4)=CC3=O)=C2)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HYS-072 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HYS-072HYS072HYS 072mTORAktApoptosisAutophagyPI3KMammalian target of RapamycinPKBProtein kinase BPhosphoinositide 3-kinasebreast cancerTriple-negative breast cancer (TNBC)MDA-MB-231anticancer activityInhibitorinhibitorinhibit

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HY-172175
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