IACS-9571 TFA (Synonyms: ASIS-P040 TFA)

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IACS-9571 (trifluoroacetate) is a potent and selective inhibitor of TRIM24 and BRPF1, with IC₅₀ of 8 nM for TRIM24, and K_d of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

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IACS-9571 TFA Chemical Structure

CAS No. : 1883598-69-3

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Other In-stock Forms of IACS-9571 TFA:

IACS-9571 hydrochloride

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Description	IACS-9571 (trifluoroacetate) is a potent and selective inhibitor of TRIM24 and BRPF1, with IC₅₀ of 8 nM for TRIM24, and K_d of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
IC₅₀ & Target	IC50: 8 nM (TRIM24)^[1] Kd: 31 nM (TRIM24), 14 nM (BRPF1)^[1]
In Vitro	IACS-9571 (trifluoroacetate) shows excellent cellular potency with EC₅₀ of 50 nM. IACS-9571 (trifluoroacetate) (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 (trifluoroacetate) is a selective dual TRIM24/BRPF1 inhibitor (K_d=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 (trifluoroacetate) does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4 (1, 2) relative to TRIM24^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. IACS-9571 TFA Related Antibodies
Molecular Weight	756.79
Formula	C₃₄H₄₃F₃N₄O₁₀S
CAS No.	1883598-69-3
SMILES	O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC(OCCC)=CC(OCCCCN(C)C)=C3)C=C(N4C)C(N(C)C4=O)=C2)=O.FC(F)(C(O)=O)F
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54. [Content Brief]

IACS-9571 TFA Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IACS-95711883598-69-3ASIS-P040IACS9571IACS 9571Epigenetic Reader DomainInhibitorinhibitorinhibit

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