2. Epigenetics
  3. Epigenetic Reader Domain
  4. IACS-9571 hydrochloride

IACS-9571 hydrochloride  (Synonyms: ASIS-P040 hydrochloride)

Cat. No.: HY-102000B Purity: 99.85%
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IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

For research use only. We do not sell to patients.

IACS-9571 hydrochloride Chemical Structure

IACS-9571 hydrochloride Chemical Structure

CAS No. : 2319611-93-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 374 In-stock
Solution
10 mM * 1 mL in DMSO USD 374 In-stock
Solid
1 mg USD 100 In-stock
5 mg USD 250 In-stock
10 mg USD 450 In-stock
50 mg USD 1650 In-stock
100 mg USD 2650 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of IACS-9571 hydrochloride:

IACS-9571 hydrochloride Related Antibodies

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Description

IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively[1].

IC50 & Target

IC50: 8 nM (TRIM24)[1]
Kd: 31 nM (TRIM24), 14 nM (BRPF1)[1]
In Vitro

IACS-9571 Hydrochloride shows excellent cellular potency with EC50 of 50 nM. IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IACS-9571 hydrochloride Related Antibodies
Molecular Weight

679.22

Formula

C32H43ClN4O8S
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

[H]Cl.O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC(OCCC)=CC(OCCCCN(C)C)=C3)C=C(N4C)C(N(C)C4=O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (184.03 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (14.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4723 mL 7.3614 mL 14.7228 mL
5 mM 0.2945 mL 1.4723 mL 2.9446 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.4723 mL 7.3614 mL 14.7228 mL 36.8069 mL
5 mM 0.2945 mL 1.4723 mL 2.9446 mL 7.3614 mL
10 mM 0.1472 mL 0.7361 mL 1.4723 mL 3.6807 mL
DMSO 15 mM 0.0982 mL 0.4908 mL 0.9815 mL 2.4538 mL
20 mM 0.0736 mL 0.3681 mL 0.7361 mL 1.8403 mL
25 mM 0.0589 mL 0.2945 mL 0.5889 mL 1.4723 mL
30 mM 0.0491 mL 0.2454 mL 0.4908 mL 1.2269 mL
40 mM 0.0368 mL 0.1840 mL 0.3681 mL 0.9202 mL
50 mM 0.0294 mL 0.1472 mL 0.2945 mL 0.7361 mL
60 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6134 mL
80 mM 0.0184 mL 0.0920 mL 0.1840 mL 0.4601 mL
100 mM 0.0147 mL 0.0736 mL 0.1472 mL 0.3681 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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IACS-9571 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IACS-95712319611-93-1ASIS-P040IACS9571IACS 9571Epigenetic Reader DomainInhibitorinhibitorinhibit

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