2. Apoptosis Others Immunology/Inflammation Anti-infection
  3. Apoptosis Isotope-Labeled Compounds COX Parasite
  4. Ibuprofen-d3 sodium

Ibuprofen-d3 sodium  (Synonyms: (±)-Ibuprofen-d3 sodium)

Cat. No.: HY-78131CS Purity: ≥99.0%
SDS
COA
Handling Instructions Technical Support

Ibuprofen-d3 ((±)-Ibuprofen-d3) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers.

For research use only. We do not sell to patients.

Ibuprofen-d<sub>3</sub> sodium Chemical Structure

Ibuprofen-d3 sodium Chemical Structure

CAS No. : 1219805-09-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Ibuprofen-d3 sodium:

Ibuprofen-d3 sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ibuprofen-d3 sodium

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Description

Ibuprofen-d3 ((±)-Ibuprofen-d3) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ibuprofen-d3 sodium Related Antibodies
Molecular Weight

231.28

Formula

C13H14D3NaO2
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])C(C([2H])([2H])[2H])C1=CC=C(CC(C)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : ≥ 50 mg/mL (216.19 mM)

DMSO : ≥ 50 mg/mL (216.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 30 mg/mL (129.71 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3238 mL 21.6188 mL 43.2376 mL
5 mM 0.8648 mL 4.3238 mL 8.6475 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / Ethanol / DMSO 1 mM 4.3238 mL 21.6188 mL 43.2376 mL 108.0941 mL
5 mM 0.8648 mL 4.3238 mL 8.6475 mL 21.6188 mL
10 mM 0.4324 mL 2.1619 mL 4.3238 mL 10.8094 mL
15 mM 0.2883 mL 1.4413 mL 2.8825 mL 7.2063 mL
20 mM 0.2162 mL 1.0809 mL 2.1619 mL 5.4047 mL
25 mM 0.1730 mL 0.8648 mL 1.7295 mL 4.3238 mL
30 mM 0.1441 mL 0.7206 mL 1.4413 mL 3.6031 mL
40 mM 0.1081 mL 0.5405 mL 1.0809 mL 2.7024 mL
50 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1619 mL
60 mM 0.0721 mL 0.3603 mL 0.7206 mL 1.8016 mL
80 mM 0.0540 mL 0.2702 mL 0.5405 mL 1.3512 mL
100 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0809 mL
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Ibuprofen-d3 sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ibuprofen-d31219805-09-0(±)-Ibuprofen-d3ApoptosisIsotope-Labeled CompoundsCOXParasiteCyclooxygenaseInhibitorinhibitorinhibit

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