1. Natural Products
  2. Disease Research Fields Plants Phenylpropanoids Phenols
  3. Solanaceae Berberidaceae Other Diseases Lignans Monophenols
  4. Capsicum annuum L. Epimedium brevicornu Maxim.
  5. Icariside E5

Icariside E5 is a lignan glycoside isolated from the Capsicum annuum. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties.

For research use only. We do not sell to patients.

Icariside E5 Chemical Structure

Icariside E5 Chemical Structure

CAS No. : 126176-79-2

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Based on 1 publication(s) in Google Scholar

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Description

Icariside E5 is a lignan glycoside isolated from the Capsicum annuum. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties[1][2].

In Vitro

Icariside E5 (5, 10, 20, 40 µM; for 48 h) slightly promotes the proliferation of human umbilical vein endothelial cells (HUVECs). Icariside E5 does not have the pharmacological effect of scavenging ROS[1].
Icariside E neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. It protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

522.54

Formula

C26H34O11

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](C1=C(C(OC)=CC(/C=C/CO)=C1)O[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)CO)CC(C=C3)=CC(OC)=C3O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Icariside E5
Cat. No.:
HY-N4020
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