ICG-Sulfo-OSu sodium

Name: ICG-Sulfo-OSu sodium
Brand: MedChemExpress
SKU: HY-134719
Rating: 4.5 (1 reviews)

Cat. No.: HY-134719 Purity: 90.26%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

ICG-Sulfo-OSu sodium Chemical Structure

CAS No. : 190714-28-4

Size	Price	Stock	Quantity
5 mg	USD 530	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

930.07

Formula

C₄₉H₅₂N₃NaO₁₀S₂

CAS No.

190714-28-4

Appearance

Solid

Color

Brown to black

SMILES

O=S(C(C1)C(N(OC(CCCCCN2/C(C(C)(C)C3=C2C=CC4=CC=CC=C34)=C\C=C\C=C\C=C\C5=[N+](CCCCS(=O)([O-])=O)C6=C(C7=CC=CC=C7C=C6)C5(C)C)=O)C1=O)=O)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (67.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0752 mL	5.3759 mL	10.7519 mL
5 mM	0.2150 mL	1.0752 mL	2.1504 mL
10 mM	0.1075 mL	0.5376 mL	1.0752 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 90.26%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (255 KB) HNMR (135 KB) LCMS (153 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0752 mL	5.3759 mL	10.7519 mL	26.8797 mL
	5 mM	0.2150 mL	1.0752 mL	2.1504 mL	5.3759 mL
	10 mM	0.1075 mL	0.5376 mL	1.0752 mL	2.6880 mL
	15 mM	0.0717 mL	0.3584 mL	0.7168 mL	1.7920 mL
	20 mM	0.0538 mL	0.2688 mL	0.5376 mL	1.3440 mL
	25 mM	0.0430 mL	0.2150 mL	0.4301 mL	1.0752 mL
	30 mM	0.0358 mL	0.1792 mL	0.3584 mL	0.8960 mL
	40 mM	0.0269 mL	0.1344 mL	0.2688 mL	0.6720 mL
	50 mM	0.0215 mL	0.1075 mL	0.2150 mL	0.5376 mL
	60 mM	0.0179 mL	0.0896 mL	0.1792 mL	0.4480 mL