2. PROTAC
  3. PROTAC Linkers
  4. ICG-Sulfo-OSu sodium

ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

ICG-Sulfo-OSu sodium Chemical Structure

ICG-Sulfo-OSu sodium Chemical Structure

CAS No. : 190714-28-4

Size Price Stock Quantity
1 mg USD 212 In-stock
5 mg USD 530 In-stock
10 mg USD 850 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

ICG-Sulfo-OSu sodium Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ICG-Sulfo-OSu sodium Related Antibodies
Molecular Weight

930.07

Formula

C49H52N3NaO10S2
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=S(C(C1)C(N(OC(CCCCCN2/C(C(C)(C)C3=C2C=CC4=CC=CC=C34)=C\C=C\C=C\C=C\C5=[N+](CCCCS(=O)([O-])=O)C6=C(C7=CC=CC=C7C=C6)C5(C)C)=O)C1=O)=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (67.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0752 mL 5.3759 mL 10.7519 mL
5 mM 0.2150 mL 1.0752 mL 2.1504 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 90.26%

COA (255 KB) HNMR (135 KB) LCMS (153 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0752 mL 5.3759 mL 10.7519 mL 26.8797 mL
5 mM 0.2150 mL 1.0752 mL 2.1504 mL 5.3759 mL
10 mM 0.1075 mL 0.5376 mL 1.0752 mL 2.6880 mL
15 mM 0.0717 mL 0.3584 mL 0.7168 mL 1.7920 mL
20 mM 0.0538 mL 0.2688 mL 0.5376 mL 1.3440 mL
25 mM 0.0430 mL 0.2150 mL 0.4301 mL 1.0752 mL
30 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8960 mL
40 mM 0.0269 mL 0.1344 mL 0.2688 mL 0.6720 mL
50 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5376 mL
60 mM 0.0179 mL 0.0896 mL 0.1792 mL 0.4480 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ICG-Sulfo-OSu sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICG-Sulfo-OSu190714-28-4PROTAC LinkersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ICG-Sulfo-OSu sodium
Cat. No.:
HY-134719
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.