2. GPCR/G Protein
  3. Bombesin Receptor
  4. ICI 216140

ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure.

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Custom Peptide Synthesis

ICI 216140 Chemical Structure

ICI 216140 Chemical Structure

CAS No. : 124001-41-8

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ICI 216140 Related Antibodies

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Description

ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure[1][2].

Molecular Weight

916.08

Formula

C45H65N13O8
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{N-Isobutyryl}-His-Trp-Ala-Val-{d-(Ala)}-His-Leu-NHMe
Sequence Shortening

{N-Isobutyryl}-HWAV-{d-(Ala)}-HL-NHMe
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (54.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0916 mL 5.4580 mL 10.9161 mL
5 mM 0.2183 mL 1.0916 mL 2.1832 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0916 mL 5.4580 mL 10.9161 mL 27.2902 mL
5 mM 0.2183 mL 1.0916 mL 2.1832 mL 5.4580 mL
10 mM 0.1092 mL 0.5458 mL 1.0916 mL 2.7290 mL
15 mM 0.0728 mL 0.3639 mL 0.7277 mL 1.8193 mL
20 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.3645 mL
25 mM 0.0437 mL 0.2183 mL 0.4366 mL 1.0916 mL
30 mM 0.0364 mL 0.1819 mL 0.3639 mL 0.9097 mL
40 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.6823 mL
50 mM 0.0218 mL 0.1092 mL 0.2183 mL 0.5458 mL
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ICI 216140 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI 216140124001-41-8ICI216140ICI-216140Bombesin ReceptorALB 3T3 cellsBombesin (HY-P0195)-stimulated pancreatic amylase secretionInhibitorinhibitorinhibit

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