IDH1 Inhibitor 5

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IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC₅₀s of 64.4 and 34.9 nM, respectively.

For research use only. We do not sell to patients.

IDH1 Inhibitor 5 Chemical Structure

CAS No. : 1940128-37-9

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IDH1 IDH2

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 64.4 nM (MOG cells), 34.9 nM (wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MOG-G-UVW	IC₅₀	64.4 nM Compound: 2	Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay	[PMID: 35450359]

In Vitro

IDH1 Inhibitor 5 (0-10 μM; 1 h) shows cellular potency in MOG cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	MOG cell line and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein
Concentration:	0-10 μM
Incubation Time:	1 hour
Result:	Showed cellular potency to MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC₅₀s of 64.4 and 34.9 nM, respectively.

Molecular Weight

450.57

Formula

C₂₆H₃₄N₄O₃

CAS No.

1940128-37-9

SMILES

CC(O[C@H]1CC[C@@H](CC1)C(N2CC3=C(NC4=C2C=C(C=C4)N5CCOCC5)N=CC=C3)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang C, et al. Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors. ACS Med Chem Lett. 2022 Mar 28;13(4):734-741. [Content Brief]

IDH1 Inhibitor 5 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDH1 Inhibitor 51940128-37-9Isocitrate Dehydrogenase (IDH)tricyclic diazepineGSH-adductanticancer2-HG reductionMOGexogenous mutantR132HInhibitorinhibitorinhibit

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