2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. IEM-1925 bromide

IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy.

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IEM-1925 bromide Chemical Structure

IEM-1925 bromide Chemical Structure

CAS No. : 258282-23-4

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Based on 1 publication(s) in Google Scholar

IEM-1925 bromide Related Antibodies

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Description

IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy[1][2].
In Vivo

IEM-1925 (10 mg/kg) weakens the behavioral motor convulsive signs of SE in rats, decreasing seizure intensity from 8 to 4 points on the Pinel and Rovner scale[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (males, weight 240-350 g)[2].
Dosage: 5, 10 mg/kg.
Administration: i.m.
Result: Administration of 5 and 10 mg/kg IEM-1925 2 h before pilocarpine did not alter the overall SE pattern. However, IEM-1925 significantly changed the latent periods of onset and durations of the separate phases and also decreased the total duration of status.
Molecular Weight

422.24

Formula

C17H30Br2N2
CAS No.
SMILES

NCCCCCNC1(C2=CC=CC=C2)CCCCC1.Br.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IEM-1925 bromide Related Classifications

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Keywords:

IEM-1925258282-23-4IEM1925IEM 1925mGluRMetabotropic glutamate receptorsglutamate receptorepilepticuspilocarpineAMPA receptorInhibitorinhibitorinhibit

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IEM-1925 bromide
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HY-103232
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